To get started, download WineBottler. Be sure to download a version that works on your release of Mac OS X. When this article was written, that meant OS X El Capitan and Yosemite users needed to download version 1.8. Open the downloaded DMG file. Welcome back, everyone. Today we cover how to run Windows native applications (specifically.exe file types) on your Mac using Wine & WineBottler. WineBottler packages Windows-based programs snugly into OS X app-bundles. No need to install emulators or operating systems - WineBottler uses the great open-source tool Wine to run the binaries on your Mac. When wanting to play video games not supported on OS X; When certain accounting tool or trading platform only works on Windows; When an audio book player isn’t available on Mac OS X; Winebottler makes how to run Windows programs on Mac simple that even a child can do it. Watch the video to see exactly how easy it is. Winebottler also does.

Winebottler Mac Review

Note: I know this is an old thread, and am just posting to help anyone else who stumbles upon this thread.

First of all: Wine (just plain wine) is NOT available for Mac, so that leave you with Wineskin, WineBottler, PlayOnMac, or CrossOver.

Wineskin and WineBottler are intended for creating wrappers, which is basically converting it to a Mac application.

Wineskin gives you more customization over your wrapper.

WineBottler also comes with a system that lets you just run any exe on mac just like that.

PlayOnMac lets you download and run supported apps easily, but isn't good for just any exe.

CrossOver is paid software.

Winebottler For Windows

If all you want to do is run exes with right-click>Open With, than install WineBottler.